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KMID : 0614020050200010041
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Journal of Pharmaceutical Sciences (C.N.U.)
2005 Volume.20 No. 1 p.41 ~ p.46
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Anaysis of acanthoic acid and isomers in Acanthopanax species by gas chromatography
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Kamg Ji-Youn
Jeong Young-Hee
Lim Eun-Hee
Lee Eun-Joo
Zhu Hong-Mei
Jeong Su-Jin
Bae Ki-Hwan
Kim Young-Ho
Kang Jong-Seong
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Abstract
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Acanthoic acid, continentalic acid and kaurenoic acid are bioactive diterpenoids which were structural isomers isolated from Acanthopanax species. For the quality evaluation of Acanthopanax species a gas chromatographic method for the separation and quantitation of these isomers was developed. Three compounds were successfully separated from the extracts of leaves, stems and roots of Acanthopanax species. GC-MS provided the identification of components separated from the extracts. Adequate separation of the components from Acanthopanax species was achieved on a fused-silica dimethyl polysiloxane capillary column (15 m x 0.25 ㎜, 0.25 ㎛ film thickness) operated with temperature programming from 160℃ held 0.5 min, increased at 11℃/min to 290℃ held 0.5 min with the carrier gas flow-rate (helium) of 5.1 ㎖/min. Among six Acanthopanax species only two species (A. koreanum and A. trifoliatus) contained the diterpenoids indication that the two species might possess the taxonomical similarity.
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KEYWORD
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Acanthopanax species, quality evaluation, diterpenoids, GC-MS
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